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A Diet Aid That Pushes the Nutraceutical Envelope
By: Mark Wright, M.D.

Benzedrine was the trade name of the racemic mixture of amphetamine (dl-amphetamine). It was marketed under this brand name in the USA by Smith, Kline and French (currently GlaxoSmithKline) in the form of inhalers, starting in 1928. Benzedrine was used to enlarge nasal and bronchial passages and it is closely related to other stimulants produced later, such as Dexedrine (d-amphetamine) and methamphetamine.

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While the drug was initially used for medical purposes, as a bronchodilator, early users of the Benzedrine inhaler discovered that it had a euphoric stimulant effect, resulting in it being one of the earliest synthetic stimulants to be widely used for recreational (i.e., non-medical) purposes. Even though this drug was intended for inhalation, many people abused it by cracking the container open and swallowing the paper strip inside, which was covered in Benzedrine. The strips were often rolled into small balls and swallowed, or taken with coffee or alcohol. The drug was often referred to as “bennies” by users and in literature. Because of the stimulant side effect, physicians discovered that amphetamine could also be used to treat narcolepsy. This led to the production of Benzedrine in tablet form. Benzedrine was also used by doctors to perk up lethargic patients before breakfast.

In 1937 the effects of Benzedrine, and thus stimulant use, was studied in children with behavior and neurological disorders. In the 1940s and 1950s reports began to emerge about the abuse of Benzedrine inhalers, and in 1949, doctors began to move away from prescribing Benzedrine as a bronchodilator and appetite suppressant. In 1959, the FDA made it a prescription drug in the United States. Benzedrine and derived amphetamines were used as a stimulant for armed forces in World War II and Vietnam.

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Over the past ten years, I have worked with the top researchers, pharmacologists, and physicians from Hi-Tech Pharmaceuticals to develop the perfect diet and energy pill. Hi-Tech has put out several blockbuster weight loss aids such as Lipodrene®, Stimerex-ES®, Fastin® and Lipodrene Xtreme®, to name a few. With the evolution of Hi-Tech’s pharmacological research into weight loss compounds, I believe we have created our finest Diet & Energy Aid!

As a bariatric (weight loss) physician, I knew of the diet and energy success of Benzedrine for decades. It had the reputation of being the strongest pill ever to hit the Market when I began my weight loss clinics. When Smith, Kline and French (now known as GlaxoSmithKline) withdrew Benzedrine from the market, it sent shockwaves through the weight loss industry. Due to its reputation in the industry I knew a new generation product with the same name was a “tall task.” Hi-Tech has been doing some exhaustive research and development on a new formula with pharmaceutical fat mobilization and apoptosis agents to create the new and improved Benzedrine™! Benzedrine’s effectiveness produced an almost cult following. In Fact, Benzedrine is also referenced in the song “What’s the Frequency, Kenneth? by R.E.M. Much earlier, in 1946, a minor hit record by Harry Gibson was, “Who Put the Benzedrine in Mrs. Murphy’s Ovaltine,” which was a song about a woman who partied at all the nightclubs and lost a lot of weight doing so. One line in the song was, “The benzedrine’s the thing that makes her swing.” On the song “Semi-Truck,” the “speed freak anthem” by Commander Cody and his Lost Planet Airmen, the singer laments his fate: “Here I sit, all alone with a broken heart. I took three bennies, and my semi-truck won’t start.”

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Benzedrine is referenced in the song “Wet Sand” by rock-funk band Red Hot Chili Peppers: “The travesties that we have seen/Are treating me like Benzedrine/ Automatic laugher from a pro. The song “Roll Up Your Sleeves” by the rapper Mickey Avalon also references Benzedrine: “Juiced on bennys and hard lemonade I boost so many sweets I’ve got tooth decay” . The drug is referenced in the song “Cherry Bomb” by Ash from their album Free All Angels: “Is she real or just a dream? / My heart beats fast like Benzedrine.” In the song “Swordfish trombones,” Tom Wait sings, “Well he packed up all his/ expectations he lit out for California/ with a flyswatter banjo on his knee/with a lucky tiger in his angel hair/ and Benzedrine for getting there...” Singer Thea Gilmore penned a song called “Benzedrine” on her 2002 album Rules for Jokers. In “Bright College Days” song Tom Lehrer proposes a toast for “beer and benzedrine”. In Sir Ian Fleming’s novel Live and Let Die, the character James Bond receives Benzedrine tablets amongst other materials intended to aid him in a mission. Bond takes a tablet and later credits its effect with preventing him from fainting after severe injury.

Unwilling to attach the name “Benzedrine” to just any diet & energy formula, Hi-Tech has spent a countless amount of time and resources to find a formula to live up to the name Benzedrine, in terms of feeling and effect. Finally, after several years of research on this project, Hi-Tech developed a formula that is so strong even Hi-Tech was hesitant to put it on the market. Hi-Tech is so confident in Benzedrine™ that they are staking their name on it in many ways as the leaders in the diet& energy industry…as the shoes Hi-Tech had to fill were very large.

Although the feeling and effect of Hi-Tech’s Benzedrine™ is at least as good as the original, the formula has changed in significant ways. The old Benzedrine formula was formulated around dl-amphetamine, while the new Benzedrine is formulated around the acacia rigidula alkaloid: N-Methyl-b-Methylphenylethylamine HCl and derivatives of this molecule. N-Methyl-b-Methylphenylethylamine HCl Phenylethylamine is an amazing compound that is naturally present in acacia rigidula. Hi-Tech has a use patent on acacia rigidula and has continued to study this amazing plant. After 5 years of researching the alkaloids in this plant Hi-Tech’s R&D team finally was able to extract N-Methyl-b-Methylphenylethylamine HCl from the plant. One of the problems we encountered while extracting this alkaloid is that acacia rigidula also contains the alpha isomer, which is Methamphetamine A.K.A. “Crystal Meth”, which is highly illegal.  As you can imagine with all the well publicized battles Hi-Tech has had with the FDA and DEA the last thing we needed was our product to contain methamphetamine. It took our overseas factory over three years to finally isolate only the beta isomer.

This compound is probably the cleanest stimulant ever researched, which has the remarkable ability to stimulate the central nervous system, without causing nervousness or the jittery feeling. N-Methyl-b-Methylphenylethylamine HCl is responsible for its beneficial effects on mood, appetite, and sense of well-being.

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Benzedrine’s Launch Represents the Largest Ever in the Diet & Energy Category!     

Hi-Tech Pharmaceuticals, Inc. knew the launch of Benzedrine™ was going to be their largest and possibly the largest in the nutritional industries history! Hi-Tech sought out to find a tablet press that could keep up with the overwhelming demand expected. Upon the mention of the Benzedrine™ launch to several of our customers we booked tens of millions of tablets of pre-orders. Hi-Tech found a press made by the German company Kilian model RX55, which was for sale from the pharmaceutical giant Novartis. Hi-Tech bought the tablet press pictured below and has it ready to produce the world’s supply of Benzedrine™. This press will run 520,000 tablets per hour and over 10 million pills daily! Most nutrition companies do not have annual capacity of what this Kilian RX55 will do in a week.
                                         
   
Benzedrine™ may be more likely to increase insomnia, decrease appetite, and increase weight loss - probably because it has a longer duration of action. In a study where patients took Benzedrine™ almost 95% reported extreme diet & energy. The molecular structure above is the molecular makeup of Benzedrine™, which is almost indistinguishable from the original. Benzedrine™ exerts its behavioral and weight loss effects by modulating the behavior of several key neurotransmitters in the brain, including
dopamine, serotonin, and norepinephrine.

The major neural systems affected by Benzedrine™ are largely implicated in the brain’s reward circuitry. Moreover, neurotransmitters involved in various reward pathways of the brain appear to be the primary targets of Benzedrine™. One such neurotransmitter is dopamine, a chemical messenger heavily active in “battle of the bulge.” That Benzedrine™ influence neurotransmitter activity specifically in regions implicated in reward provides insight into the behavioral consequences of the drug, such as the stereotyped onset of euphoria. Endogenous amphetamines- Amphetamine has been found to have several endogenous analogues; that is, molecules of a similar structure found naturally in the brain. L-Phenylalanine and â-Phenylethylamine are two examples, which are formed in the peripheral nervous system as well as in the brain itself. These molecules are thought to modulate levels of excitement and alertness, among other related affective states.

Dopamine- Perhaps the most widely studied neurotransmitter with regard to amphetamine action is dopamine, the “reward neurotransmitter” that is highly active in numerous reward pathways of the brain. Various studies have shown that in select regions, amphetamine increases the concentrations of dopamine in the synaptic cleft, thereby heightening the response of the post-synaptic neuron. Benzedrine’s unique ability to influence dopamine causing you to “feel good” is why most people talk about the ability to not binge as they feel rewarded or satisfied and not hungry. Benzedrine is the only dietary supplement that has been shown to significantly increase the amount of dopamine in the bloodstream, which is why everyone who has tried Benzedrine™ during our R&D phase raved about its incredible effects.

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Benzedrine: The First Anorectic Dietary Supplement Ever Produced  

Anorexics, anorexigenics or appetite suppressants are substances (dietary supplements or drugs) that reduce the appetite and cause a person to eat less. The word comes from the greek an- = “without” and orexi- = “appetite”.

Benzedrine works much like Phen-Fen as it has a Stimulant that triggers release of  Norepinephrine and Dopamine, and it has a active ingredient that works on serotonin. Benzedrine does not cause heart valve issues like were found when Phen-Fen was released. Benzedrine will revolutionize the diet & energy category with its ability to effectively work on all three neurotransmitters.

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